Reduced Leishmania (L.) infantum chagasi parasitic loads in humans exposed to Lutzomyia longipalpis bites in the Amazon region of Brazil
نویسندگان
چکیده
MÁRCIA DALASTRA LAURENTI*, LUIS FERNANDO CHAVES, THAÍSE YUMIE TOMOKANE, IBRAHIM ABBASI, ALON WARBURG and FERNANDO TOBIAS SILVEIRA Laboratory of Pathology of Infectious Diseases, Department of Pathology, Medical School, University of São Paulo, São Paulo (SP), Brazil Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica Programa de Investigación en Enfermedades Tropicales (PIET), Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica 4 Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan The Department of Microbiology and Molecular Genetics, The Kuvin Center for the study of Infectious and Tropical Diseases, The Institute of Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel 6 Instituto Evandro Chagas, Ministry of Health, Ananindeua (PA), Brazil Nucleous of Tropical Medicine, Federal University of Pará, Belém (PA), Brazil
منابع مشابه
Discovery of Markers of Exposure Specific to Bites of Lutzomyia longipalpis, the Vector of Leishmania infantum chagasi in Latin America
BACKGROUND Sand flies deliver Leishmania parasites to a host alongside salivary molecules that affect infection outcomes. Though some proteins are immunogenic and have potential as markers of vector exposure, their identity and vector specificity remain elusive. METHODOLOGY/PRINCIPAL FINDINGS We screened human, dog, and fox sera from endemic areas of visceral leishmaniasis to identify potenti...
متن کاملLutzomyia longipalpis in Brazil: a complex or a single species? A mini-review.
Lutzomyia longipalpis is the main vector of Leishmania infantum chagasi, the causative agent of American visceral leishmaniasis (AVL). Although there is strong evidence that Lu. longipalpis is a species complex, not all data concerning populations from Brazil support this hypothesis. The issue is still somewhat controversial for this large part of Lu. longipalpis distribution range even though ...
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The main vector for visceral leishmaniasis (VL) in Brazil is Lutzomyia longipalpis. However, the absence of L. longipalpis in a region of autochthonous VL demonstrates the participation of other species in the transmission of the parasite. Studies conducted in La Banda, Argentina, and São Vicente Férrer, Pernambuco State, Brazil, have correlated the absence of L. longipalpis and the presence of...
متن کاملEpidemiological survey of Lutzomyia longipalpis infected by Leishmania infantum in an endemic area of Brazil Levantamento epidemiológico de Lutzomyia longipalpis infectada por Leishmania infantum em área endêmica do Brasil
The objective of this study was to perform an epidemiological survey to determine the areas at risk of visceral leishmaniasis through the detection and quantification of natural infection by Leishmania infantum in Lutzomyia longipalpis. The sandflies were captured between February 2009 and January 2010, at 21 sites in four regions of the Fortaleza municipality. Samples were screened for the pre...
متن کاملThe Gut Microbiome of the Vector Lutzomyia longipalpis Is Essential for Survival of Leishmania infantum
The vector-borne disease leishmaniasis, caused by Leishmania species protozoa, is transmitted to humans by phlebotomine sand flies. Development of Leishmania to infective metacyclic promastigotes in the insect gut, a process termed metacyclogenesis, is an essential prerequisite for transmission. Based on the hypothesis that vector gut microbiota influence the development of virulent parasites, ...
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